Novel Anticancer curcumin analog
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Novel Anticancer Curcumin Analog By Indian Scientists

With ameliorated measures taken to explore anti-cancer therapies, an elite group of Indian researchers has discovered a method to regulate the oncogenic activity of c-myc (cancer myelocytomatosis), employing a synthetic analog of Curcumin derived from Turmeric.

Proto-oncogenes, a group of genes are present in all living bodies. They serve a crucial function in the division, differentiation, and death of cells. Healthy cells produce these genes in an extremely controlled way. As a result, they work very accurately. Nevertheless, these genes can undergo mutation or multiply in large quantities due to environmental or genetic parameters, transforming proto-oncogenes to rogues or oncogenes. This further leads to an uncontrolled cell activity with either continuous expression or expression when not required, ultimately resulting in cancer.

Prior studies have reported cancer myelocytomatosis as an exceedingly dynamic oncogene in various cancer conditions. Researchers investigating anti-cancer therapies have been focussing on this oncogene, making it significant. Certain findings have been observed and operations are afoot to formulate drug products.

Curcumin, a natural antitumor molecule, is derived from the roots and rootstocks of turmeric (Curcuma longa). It has been found to have various therapeutic applications, particularly in targeting bacteria, fungi, viruses

, cancer, and oxidation. Nonetheless, it has certain demerits like reduced efficacy and limited bioavailability.

The novel research performed by the joint force of scientists from IIT-(Indore, Bombay, Jodhpur) and RRCAT(Raja Ramanna Centre for Advanced Technology) assures to resolve this constriction posed by curcumin. The investigation team, headed by Dr. Amit Kumar, IIT-Indore, scouted various synthetic analogs of Curcumin and discovered an analog termed Cur-4, a novel anticancer curcumin analog, which is befitting for the purpose.

Dr. Kumar asserted while reporting to India Science Wire that Curcumin is found to be a highly potent dietary supplement popularly utilized in India periodically in routine diets. He said that now they have determined an analog that exhibited potent anticancer function. They believe their findings will result in the emergence of an efficient medicine again.

The research team comprised of Nirali Pandya, Neha Jain, Rahul Sigh, Amit Mishra, Eshan Khan, Laksminarayana Satham, and Ravindra D. Makde from IIT Jodhpur, apart from Dr. Kumar. They have also issued an article in Elsevier’s Biochimie, explicating their work.

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Author : Geema George

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