DBT India Mission Program on Antimicrobial Resistance
GoI, DBT has initiated a major Mission program on Antimicrobial Resistance. Letters of Intent are encouraged from Indian Nationals for Mission Program on Antimicrobial Resistance. Check out all of the details on the same below:
This call expires in :
Antimicrobial resistance (AMR) is one of the major threats to human health in the 21st century, with some bacterial pathogens acquiring resistance to all clinically available antibiotics. Worldwide, infections caused by multi-drug resistant (MDR) bacteria are now a major cause of morbidity & mortality and have markedly enhanced healthcare costs. Considering AMR as a National priority, under National Action Plan endorsed by Govt. of India, the Department of Biotechnology has initiated a major Mission program on Antimicrobial Resistance with the vision to develop indigenous and cost-effective therapies against AMR; categorization of AMR specific pathogen priority list of India; establishment of Bio-repository for AMR-specific pathogens; and development of rapid and cost-effective diagnostic kits to identify AMR-specific pathogens.
Considering AMR as the topmost national priority, the Department has notified National Centre for Microbial Resource (NCMR), National Centre of Cell Sciences, Pune (an Autonomous Institute of DBT) to function as Bio-repository for resistant microbes/infective agents (Bacteria and Fungi)” and to carry out collection, storage
, maintenance, preservation and characterization of these microbes across the country. Further, the Department is working to share the information regarding National AMR-specific Pathogen list which will be available very soon including a landscaping report on existing rapid and cost-effective diagnostic kits to identify AMR-specific pathogens.In a process to fulfill the ambition of this program, Department of Biotechnology (DBT) in collaboration with Biotechnology Industry Research Assistance Council (BIRAC) invites preproposals in the area of development of new antibiotics and alternatives to antibiotics to counter AMR.
Introduction of DBT-BIRAC Joint call:
Considering AMR as a major public health threat, the Department of Biotechnology,
Government of India has announced this Joint call with the Biotechnology Industry Research Assistance Council (BIRAC) on antimicrobial resistance (AMR). This joint DBT-BIRAC call will focus on the aforementioned two specific mandates and will leverage the funding expertise of both the organizations. This initiative focuses on nurturing collaborations between academia and industry partners to enhance their capabilities and competencies for developing new antibiotics and alternative therapeutics for AMR.
Aim of the Call:
With the aim to discover, develop and exploit new resources for antibiotics and alternatives to antibiotics, under this joint Call, the Department is seeking concept note/pre-proposals under following two categories:
A. Development of new antibiotics
B. Development of alternatives to antibioticsa.
Therapeutic antibodies
b. Phage therapy and
c. Anti-biofilm products
Scope of this Call:
From this joint Call, the Department seeks new innovative approaches that have the potential to transform public health action on a national or global scale by identifying and filling gaps in knowledge on the development of drugs to counter AMR. This Joint Call is aimed to support collaborative proposals that combine complementary and synergistic research strengths in any one of the aforementioned categories/sub-categories. The following pre-proposals would be encouraged for support:
1. Consortia-based concept notes/pre-proposals from academia (with/without industry) with already established/identified leads and explicitly outlined deliverables for further validation.
2. Innovative proposals with an established proof-of-concept.
3. Investigations based on or involving clinical trials
[* Proposals that address the bacterial pathogens and the resistance identified in the Global priority list of antibiotic-resistant bacteria published by the WHO and multi- and extensively drug resistant Mycobacterium tuberculosis will only be considered.]
Expectation of the Call:
The call will cover research addressing the following topics:
1. Identification of new bacterial targets and/or therapeutic compounds.
2. Re-evaluation of existing anti-microbial compounds either alone or in combination with
other drugs or immune-modulators.
3. Investigation of the novel enzyme(s)/ targets/ mechanisms to overcome known antimicrobial
resistance mechanisms and restore susceptibility to conventional antibiotics.
4. Investigation of alternative therapeutics that enhances immune pathogen elimination through therapeutic antibodies & phage therapy and disrupts colonization & bio-film development through anti-biofilm products.
Not within the scope of the call:
1. Over-ambitious investigations encompassing both the categories/clubbing two or more subcategories of alternatives to antibiotics.
2. Individual projects with limited R&D value.
3. Proposals focusing only on knowledge generation without a drug candidate/alternative
candidate. These may include:
a. Investigations addressing cross-talk between the host and pathogen, as well as the
relationship between microbes, environment and infection.
b. Assessing the role of commensal flora in homeostasis and microbe’s pathogenicity, and
elucidating how commensal organisms or pro-biotics can be used to prevent or treat
infections.
c. Investigations on initial steps of the infection process.
4. Studies on bacteria not on the WHO Global priority list.
5. Investments in research infrastructures are not covered under this call
Primary Applicant: The primary applicant for this call is mandatorily academia either alone or with industry.
Collaborations: Collaborative proposals would be encouraged. These may be:
1. Academia with academia
2. Academia with industry
Please note that even for collaborators, the basic eligibility criteria as below needs to be met.
Eligibility criteria:
Please note the following eligibility criteria carefully
1. Eligible Organizations
a. Central/State Govt. Institutions of Higher Education
b. Private Institutions of Higher Education
c. Research institutes, universities, medical schools, IIT’s and other engineering institutions,
other recognized research laboratories in the public sector and not-for-profit institutions.
d. The institution must be recognized by DSIR as a Scientific and Industrial Research
Organization (SIRO), if outside public sector.
2. Required Registrations
Private institutions/Hospitals/ NGOs should be registered in Darpan Portal, Niti Aayog website
3. Eligible Individuals-Principal Investigator(s)
Scientists working in Universities/Academic Institutions/National Laboratories/Industries
[Department of Scientific & Industrial Research (DSIR)-Recognized R&D Centre] & Non-Profit Organizations with necessary facilities and strong scientific background in the proposed area as the Principal Investigator(s) are invited to develop an application for support.
4. Eligible Industry (Companies)
An Indian company is defined as one which is registered under the Indian Companies Act, 2013 and a minimum 51% of shares of the Company should be held by Indian citizens holding an Indian passport. (Indian Citizens do not include Persons of Indian Origin (PIO) or Overseas Citizen of India (OCI) holders).
Submission Process:
The proposal submission is in two phases:
1. Phase I: Letter of Intent (LOI) – In this phase, interested applicants may apply through a LoI to be submitted online on the link provided.
2. Phase II: Full proposal – successful LoIs will be invited to submit full proposals in this phase.
Evaluation criteria:
1. Scientific merit
2. Clarity of hypothesis
3. Relevance and ability to implement approaches
4. Background of the investigator
5. Feasibility of conducting the research in the present settings
Evaluation process:
1. In Phase I, only LoIs will be accepted through the online system.
2. These will be evaluated by an experts committee and successful LoIs will be invited to submit
full proposals.
3. The full proposals will be evaluated by Technical Expert Committee.
4. Final recommendations will be communicated.
Mode of Submission:
LoIs may be submitted in the prescribed format (Annexure-I), clearly stating “Request for Application: Innovative Approaches to address Antimicrobial resistance” through online: http://dbtepromis.nic.in/pi/loi.aspx. Subsequently, two hard copies should also be sent to Dr Vinita N. Chaudhary, Scientist ‘E’, Department of Biotechnology, Block- 2, Room No.816, 8th floor, CGO Complex, Lodhi Road, New Delhi – 110003.
Below mentioned are the steps to submit LOI.
1. Open dbtepromis.nic.in website
2. Sign in into your account
3. Click on Login as PI button
4. PI user interface page will open
5. Now copy paste the link http://dbtepromis.nic.in/pi/loi.aspx
For any queries please contact:
Dr Sundeep Sarin, Adviser, DBT: [email protected]
Dr Vinita Chaudhary, Joint Director, DBT: [email protected]
Dr Aparna Sharma, Manager-Technical, BIRAC: [email protected]
Timeline:
- Call for LoI opens: 1st October 2018
- Call for LoI closes: 15th November 2018
- LoI Selection by 31st December 2018
- Full proposal submission: 31st January 2018
- Full proposal selection by 15th March 2018
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Editor’s Note: DBT India Mission Program, DBT India Mission Program on Antimicrobial Resistance, GoI DBT India Mission Program. Check out the YouTube channel for the latest biosciences updates and also make sure you are subscribed to the Biotecnika Times Newsletter.
