The Dr. Reddy’s Institute of Life Sciences was conceived in the context of globalization, to foster research competence in India and to bridge the divide between academic research and the pharmaceutical & biotechnology industries.
PROJECT TITLE : A mechanistic study of the recruitment of the nuclear RNAi machinery for de novo establishment of heterochromatin domains in S.pombe
FUNDING AGENCY : DBT
Position:
Junior Research Fellow with any one of the following:
- Post Graduate Degree in Basic Science with NET qualification (M.Sc.Biochemistry/Biotechnology/Genetics/Molecular Biology etc)
- Graduate Degree in Professional Course with NET qualification (B.Tech. Biotechnology or similar)
- Post Graduate Degree in Professional Course ( M.Tech. Biotechnology or similar)
NETs accepted : CSIR-NET including LS; GATE, JAM, GPAT, BET, JEST, JGEEBILS, ICMR-JRF and ICAR- AICE
Candidates with a keen interest in basic science research and prior hands-on experience with molecular Biology, biochemistry or microbiology techniques are preferred. A possibility of Ph.D enrollment exists, however it is not guaranteed.
EMOLUMENTS : Rs. 25000+HRA per month
Project duration : 3 years. Appointment will be renewed yearly contingent on performance.
PROJECT SUMMARY
In eukaryotes, heterochromatin domains play a key role in packaging, protecting as well as regulating the expression of the genetic material. In S.pombe, the
nuclear RNA interference (RNAi) machinery is involved in the formation of heterochromatin and it appears likely that a similar process may function in mammalian cells. In this proposal, we aim to address the following questions: How does the first wave of the RNAi machinery localize to the repeats, what role do the DNA or RNA sequences play in this process? What is the kinetics of this process and is there an order of assembly and a time scale associated with it? This information is important especially in the context of data that implicates the nuclear RNAi pathway in the setting up facultative heterochromatin in mammalian cells, and playing a role in development, chromosome segregation and surveillance.The successful outcome of this study will identify sequence elements that are essential for de novo establishment of heterochromatin and silencing. In addition, we will also be able to generate a kinetic roadmap of how the RNAi machinery is recruited and silencing established.
How to Apply :
Qualified and interested candidates may send their curriculum vitae by e-mail to [email protected] on or before deadline, mention in the subject line of the mail the following code: – Heterochromatin- Biology
Selected candidates will be called for a personal interview to Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad.
Candidates will not be reimbursed for Travel for the Interview, if short listed
DEADLINE : 15th December, 2016
