Incorporated in the year 1994, Syngene International is one of India’s premier contract research and manufacturing organizations in providing customized service. Our services encompasses all across discovery chain: early stage discovery, process development, cGMP manufacturing and formulation development both in the small molecule and novel biologics area.
Job Title : Research Investigator in Biotransformation
Experience : 0 – 5 Years
Location : Bengaluru/Bangalore
Salary : INR 60,000 – 3,00,000 P.A
Job Description
Project Responsibilities: Provide comprehensive biotransformation support to assigned programs starting from carrying out experiments, analyzing data, preparing presentations, discussing with key stakeholders and presenting to the discovery team. Participating in relevant meetings and proactively proposing experiments to understand or improve molecule properties from a biotransformation perspective. Perform all this within defined time lines and meeting defined quality expectations.
Group Responsibilities: Provide leadership within the group which involves mentoring associates in biotransformation, drug discovery and instrumentation and providing them with day to day guidance and long term development. Take accountability and responsibility for smooth group operations including instrument maintenance and upgrades, inventory management and metric tracking. Assist in sharing and inculcating best practices across the group.
Capability Development Responsibilities: Work on exploratory and capability development projects as relevant to
the organization. Manage and delegate these projects and provide own vision and guidance to these projects.People Responsibilities: Work closely with peers, associates and other members of the department to eliminate bottlenecks and facilitate smooth communications and transactions. Likewise, work closely with other members of discovery team to enable meeting project objectives.
Metabolism Responsibilities: Interact with the metabolism group to be familiar with their assays and provide bench level, technical and conceptual support as needed.
Any other duties given from time to time in Operations by the line manager
Qualification & Experience:
PhD and postdoctoral experience in a relevant field and two years of relevant experience.
Desired Profile
Skills :
- Expert in handling a mass spectrometer
- Expert in biotransformation fundamentals and enzymology.
- Expert in conducting metabolite identification experiments
- Understanding of advanced biotransformation studies such as bile duct cannulated studies and reaction phenotyping.
- Well versed in identifying reactive metabolites and advising the team in avoidance strategies
- Basic understanding of inhibition and metabolic stability assays.
- Basic understanding of lead optimization in drug discovery.
- Excellent written and oral communication skills
- Excellent documentation abilities
- Excellent inter-personal relationships
Key Competencies :
- Ability to learn understanding and application of information & concepts.
- Thoroughness accuracy, precision & completion
- Sense of urgency
- Flexibility and adaptability – embracing change willingly; openness to new ideas, information and situations with consequent alteration of opinion & behavior in a positive sense.Interfaces and Dependencies
Internal : manager, department head, department extended leadership team, biotransformation and metabolism group
External: BMS project counterparts, BMS biotransformation team, BMS mentors, BMS advisors
