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Computational Biology Jobs at 4Basecare – Apply on Biotecnika
Job Title: Bioinformatics Analyst
Location: Bangalore
Company: 4Basecare
Experience: 1.5 to 2 years
Salary: Hike on last salary
Role Overview
We are seeking a motivated and detail-oriented Bioinformatics Analyst with 1.5 to 2 years
of experience to support clinical NGS data analysis in a high-throughput environment. The
role involves executing and optimizing analysis pipelines, curating clinical data, and
collaborating closely with the reporting and genomics teams. The ideal candidate will work
hands-on with genomic data and contribute to best practices in clinical bioinformatics.
Key Responsibilities
• Curate and organize genomic and clinical data from multiple sources to support DNA-
seq and RNA-seq interpretation.
• Execute and troubleshoot clinical sample analysis using validated pipelines for Whole
Exome Sequencing (WES), targeted gene panels, and transcriptome (RNA-seq) data.
• Assist in developing and optimizing bioinformatics pipelines using tools such as
DRAGEN, Nextflow, and Docker, under guidance from senior team members.
• Support the reporting team by preparing genomic visualizations (e.g., CNA graphs,
allelic burden plots, fusion summaries).
• Stay updated on emerging tools, databases, and NGS workflow improvements;
contribute to team-wide knowledge sharing.
Technical Skills
• Programming/Scripting: Proficiency in Python and/or R; working knowledge of
Shell scripting and Git.
• Data Analysis & Statistics: Familiarity with libraries such as pandas, scikit-learn,
tidyverse for basic statistical analysis.
• NGS Tools: Experience with tools like GATK, BWA, STAR, Salmon, SAMtools,
etc.
• Workflow Management: Exposure to workflow systems like Nextflow,
Snakemake, or basic Docker and Linux operations.
Experience & Education
• Master’s degree (or equivalent) in Bioinformatics, Genomics, Computational Biology,
or related field.
• 1.5 to 2 years of practical experience in clinical or applied NGS data analysis.
• Working knowledge of variant calling, CNV detection, and fusion analysis
workflows.
Soft Skills
• Strong attention to detail in data processing and documentation.
• Willingness to learn and contribute in a collaborative, cross-functional environment.
• Good communication skills and ability to coordinate with technical and clinical
teams.
• Problem-solving mindset with curiosity to improve workflows.
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