Muscle Regeneration after physiological damage
Muscle regeneration is comprehended to be a complex process involving various steps and relying on stem cells. A novel study headed by a team from iMM, Portugal, and UPF, Spain, explains a unique mechanism for muscle regeneration after physiological damage that relies on nuclei rearrangement. This protecting mechanism paves the direction for a more comprehensive perception of muscle repair.
Skeletal muscle tissue, the organ accountable for movement, is made up of cells with multiple nuclei, which is essentially a novel feature in our body. Regardless of the plasticity of muscle cells, contraction can result in muscle damage.
Even in physiological conditions, regeneration is critical for the muscle to sustain the mechanical pressure of contraction, which usually results in cellular damage, stated William Roman, the lead author of the study and researcher at iMM and UPF Barcelona. Even though muscle regeneration has been extensively researched in recent years, most researches have concentrated on mechanisms involving other cells, such as muscle stem cells, which are needed upon extensive muscle damage.
Pura Muñoz-Cánoves, group leader, UPF, and study leader, stated that
they discovered another mechanism of regeneration that is muscle cell-autonomous. The team used various in vitro models of injury and exercise models in mice and humans to see nuclei being drawn to the injured site, stimulating the restoration of contractile units. The researchers then dissected the molecular mechanism of this conclusion: Their lab tests revealed that the nuclei move to the site of injury, which leads to local delivery of mRNA.William Roman described that these mRNA molecules translate into proteins at the injured sites to serve as building blocks for muscle repair. Pura Muoz-Cánoves comments on the significance of these discoveries that this outcome constitutes a major advance in the understanding of muscle biology, physiology, and muscle dysfunction.
This research not only highlights muscle research but things like basic concepts for cell biology, like nuclear movement to the injured sites. One of the most interesting aspects of these cells is the movement of their nuclei, the largest organelles inside the cell, during development. However, the causes why nuclei move are mostly undiscovered.
Edgar R. Gomes, co-author, group leader, iMM, and Professor at the Faculty of Medicine, University of Lisbon, stated that the study had demonstrated a functional significance for this phenomenon in adulthood during cellular repair and regeneration.
The findings of the study – Muscle Regeneration after physiological damage, are released in the journal Science.
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Keywords: Muscle Regeneration after physiological damage; mRNA
