CCM Biosciences Scientists Discover Groundbreaking Longevity Therapeutics
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CCM Biosciences Scientists Discover Groundbreaking Longevity Therapeutics

Can we really reverse the effects of aging at the cellular level?

Well, this age-old question has given birth to years of research and CCM Biosciences may have just found something revolutionary answer to it. CCM Biosciences scientists have made a groundbreaking discovery in developing a new class of therapeutics to extend lifespan and treat age-related diseases.

They discovered compounds that are enzyme activators and further restore a mitochondrial regulator of aging that was previously undruggable. This also has benefits to fight against various age-related disorders. However, the process faced significant challenges, particularly due to hurdles in allosteric modulation.

Enzyme Activity

Enzymes play an essential role in cellular processes, and the compounds that further enhance enzyme activity have a high potential to contribute to cellular rejuvenation therapy. These compounds work by boosting the activity of enzymes involved in energy production and other critical cellular functions. According to CCM Biosciences, by targeting and improving these enzymes, the compounds could contribute to healthier, longer-lasting cells, offering a potential breakthrough in treating age-related diseases like Alzheimer’s, Parkinson’s, and cardiovascular conditions.

Allosteric Modulation Challenge

In the past, enhancing enzyme activity has been a difficult task because most

of the available methods used to rely on a mechanism called allosteric modulation. The allosteric modulation process only works for about 10% of proteins, which further makes it challenging to find suitable compounds for a broader range of enzymes, especially those crucial in aging processes. CCM Biosciences overcame this hurdle by developing a new approach to enzyme activation, expanding beyond traditional methods to discover compounds that effectively target and activate a previously “undruggable” mitochondrial enzyme known as SIRT3.

SIRT3: A Key Player in Aging

SIRT3 is an enzyme involved in regulating mitochondrial function, they are the powerhouse of the cell but it declines naturally with age. Researchers had struggled to find ways to enhance SIRT3 activity in a meaningful way, as there was no known allosteric site that could be targeted for activation. However, the compounds discovered by CCM Biosciences increase the enzyme’s sensitivity to NAD+, a vital cofactor that decreases as we age. This boost in SIRT3 activity could help reduce the effects of aging and promote better cellular health.

The Cost to Add One More Year

It is estimated that the ability to add just one year of healthy life could be worth over $10 trillion. The largest XPRIZE in history was recently announced with a seven-year plan to rejuvenate cells. They can also reduce the risks of many chronic and age-related disorders by enhancing the activity of enzymes that regulate biochemical signaling pathways.

The Future of Longevity Therapeutics

These groundbreaking compounds are already showing positive results just in the initial phases of experiments, where they have outperformed other approaches like NAD+ supplements in improving SIRT3 activity. Additionally, animal testing has demonstrated their potential to combat age-related disorders, with ongoing studies showing improvements in conditions such as infertility. CCM Biosciences is moving forward with plans to test these compounds in clinical trials in 2025.

Dr. Michael Pollak, a professor of medicine in oncology and pharmacology, said that there have been efforts to activate sirtuin-regulated pathways to treat age-related disorders for decades. However, these attempts have faced many challenges. CCM Biosciences has made significant progress by designing drug candidates that can activate the mitochondrial pathways which are controlled by sirtuins. Their plan to test these drugs for both effectiveness and safety is bringing new hope to this area of drug development.

The groundbreaking work by CCM Biosciences marks a significant milestone. This discovery brings hope for revolutionizing how we approach aging and age-related diseases. As clinical trials approach, we are eagerly expecting the potential impact of this revolutionary therapeutic approach. If these trials prove successful, CCM Biosciences’ work will not only validate decades of scientific inquiry but also offer a profound opportunity to extend the human health span and address some of the most pressing health challenges of our time.

CCM Biosciences Scientists Discover Groundbreaking Longevity Therapeutics

Further Reading: https://journals.aps.org/prx/abstract/10.1103/PhysRevX.14.041019

Press Release: https://ccm-bio.com/wp-content/uploads/2025/01/Longevity-Therapeutics.pdf

Diluxi Arya
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