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Pfizer, DL Medicine Form Drug Discovery Alliance

Chinese NetVation DL Medicine will now be collaborating with Pfizer through a two-year research deal. Under the terms of the agreement, DL Medicine will screen and collaborate with Pfizer in producing new chemical entities against pre-selected targets from multiple therapeutic areas. As part of the collaboration, Pfizer has taken a financial stake in DL Medicine.

DL Medicine is developing a drug discovery platform to identify novel, potent chemical lead matter to bring into development against druggable and previously undruggable targets. Pfizer took an undisclosed stake in DL Medicine in the form of convertible notes, according to a Pfizer spokesperson. Financial terms of the deal are not disclosed.

Research conducted under this collaboration will utilize HitGen’s DNA-encoded libraries to validate early targets, identify novel chemical matter, and conduct lead optimization.

HitGen uses DNA sequences to generate extensive compound libraries, which can then be screened against targets. Once compounds with strong binding to a target are found, the structure of the “hits” can be deciphered using high-throughput DNA sequencing and the compounds optimized for further development. It’s a hugely productive process, and HitGen says it has built DELs with more than 85 billion compounds.

Dr Wei Chen, CEO of DL

Medicine, said: “We are delighted to announce this collaboration with Pfizer, and we look forward to working together to potentially discover new chemical entities for the treatment of diseases that negatively impact the health of patients worldwide.

New target ideas and novel chemical matter are critical to our success in bringing new therapies to patients around the world,” said Yuan-Hua Ding, Executive Director, External Science & Innovation, Pfizer. “This collaboration represents our worldwide commitment to partnering with companies that are doing innovative scientific work to help enhance our portfolio across multiple disease areas.

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