DBT-THSTI Study On Tuberculosis
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DBT-THSTI Study On Tuberculosis

Mycobacterium tuberculosis (MTB), a bacterial pathogen that predominantly attacks the lungs causing the highly infectious disease, tuberculosis (TB). Many people are affected by it without showing any symptoms and it is a leading cause of death worldwide. The bacterium is able to survive inside the macrophages that are supposed to kill it as it has co-evolved with humans and learned to replicate. The proteins responsible for killing bacterial pathogens are altered by the infection of macrophages by the bacterium.

A comparative study of the complete set of phosphorylated proteins of macrophages on being infected by TB and a non-pathogenic bacterium called Mycobacterium Bovis (BCG) was carried out by the researchers at the Department of Biotechnology’s Translational Health Science and Technology Institute (DBT-THSTI), Faridabad, in order to understand these protein modifications better.

The cellular response in our body can be regulated with the help of phosphorylation, which is one of the most crucial protein modifications. The differences in the macrophage response on being infected by a non-pathogenic and a pathogenic bacterium were determined by researchers in this study. The entire set of proteins of macrophages undergoing phosphorylation is studied in order to carry this out.

The best

method considered to compare pairs of protein samples efficiently, mass spectrometry, is the technique that is used here. In the immune response during viral infection, cytosolic RIG-1, a macrophage protein is known to play an essential role. To fight the pathogens, this protein release a number of chemical mediators which triggers an immune response. These proteins are found to perform a contradictory role in response to MTB infection, they aid in the survival of MTB in macrophages.

This is the first research study to provide information on relative and quantitative protein modifications in the complete set of proteins of macrophages. New information is provided on the differential sites in macrophages proteins where protein modifications occur. Protection through prospective vaccine candidates and unexplored pathways useful in controlling tuberculosis can be understood with the help of this. Also in designing new drug targets for treating tuberculosis, this could prove to be useful in the future. Macrophagic proteins for drug designing can be targetted by protein modification sites.

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DBT-THSTI Study On Tuberculosis

2 COMMENTS

  1. I completed MPharm, MBA, Ph.D. from Madras Medical College, Chennai and currently working as an assistant professor at Sathyabama institute of science and technology, Chennai. M y research was in newer drug discovery for tuberculosis and synthesized about 35 novel molecules as antitubercular agents. Studied invitro and in vivo study and filed a patent in India also. Te same molecules also tried for neurological study and found tat very wonderful effect and happy to share that, we received a patent from south Korea for my work. I wish to extend my research work. Research is my passion and always wishes to walk to achieve my dreams and looking for a suitable platform for that. I need to balance my personal life and professional life. Looking forward to read from you. Happy hours. Thank you…Thank you.

  2. I wish to extend my research work. Research is my passion and always wishes to walk to achieve my dreams and looking for a suitable platform for that. I need to balance my personal life and professional life. Looking forward to read from you. Happy hours. Thank you…Thank you.

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