Project-SRF position at Regional Center for Biotechnology – Applications are invited – MSc Life Sciences/Biology graduates – Apply below
Advt. No. 25/Project/2023/HR
Interview for Project-SRF position
Title of Project : Elucidating the Structural characteristics of pilus components from Enterococcus faecalis, an opportunistic pathogen of the Urinary tract.
Duration : Initially six months may be extended until the duration of the project based on evaluation.
Essential Qualifications : Post Graduate Degree in Life Sciences/Biology or associated field with any National Level Test and two years of research experience.
Desirable Qualifications : Research experience in structural biology including gene cloning, protein purification, crystallization, X-ray crystallography, structural bioinformatics, biophysical techniques, and cryo-electron microscopy. Good oral and written communication skills. A strong motivation for a career in research.
Principal Investigator : Dr. Vengadesan Krishnan, Professor
No. of Position : One
Emoluments : Rs. 35,000/- + 24% HRA per month as per guidelines.
Interested candidates should apply online by 25th September, 2023, 5:00 PM.
The shortlisted candidates will be informed by 29th September, 2023 via email to appear in the online interview to be held at 2:30 PM onwards on 5th October, 2023.
For any query, you may contact PIby email : [email protected]
Please upload copies of the following documents:
1) M.Sc. marksheet in Life Sciences/Biotechnology.
2) National Level JRF eligibility test certificate.
3) Peer-reviewed, published manuscript, if any.
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Here are some potential interview questions and sample answers for the Project-SRF position:
- Can you explain your research experience in structural biology, including the techniques you have used?Sample Answer: In my previous research positions, I have extensively worked in the field of structural biology. I have experience in gene cloning, where I designed and cloned target genes for expression. I have also conducted protein purification using various chromatography techniques to obtain highly pure protein samples. Additionally, I have worked on crystallization trials to produce protein crystals suitable for X-ray crystallography. Moreover, I have used structural bioinformatics tools to analyze protein structures, predict binding sites, and perform structure-based functional annotations. Furthermore, I have utilized biophysical techniques like circular dichroism spectroscopy and isothermal titration calorimetry to characterize protein-ligand interactions. Lastly, I have been involved in cryo-electron microscopy experiments to visualize macromolecular complexes at high resolution.
- Could you discuss a specific research project or publication that highlights your expertise in structural biology?Sample Answer: Certainly. One of my notable research projects involved the structural elucidation of a key enzyme involved in antibiotic resistance in Gram-positive bacteria. We successfully cloned the gene, purified the protein, and obtained high-quality crystals suitable for X-ray crystallography. The resulting crystal structure revealed important insights into the enzyme’s mechanism of action and provided a foundation for potential drug design. This work was published in a peer-reviewed journal [mention the journal and publication details] and has been cited by other researchers in the field.
- How do you plan to contribute to this specific project on Enterococcus faecalis pilus components?Sample Answer: I believe my background and experience in structural biology align perfectly with the goals of this project. I am eager to contribute by employing my expertise in gene cloning, protein purification, and crystallization to isolate and characterize pilus components from Enterococcus faecalis. Additionally, I can utilize structural bioinformatics tools to predict the structural features of these components and potentially identify binding sites. Furthermore, I am proficient in biophysical techniques, which will be valuable for studying the interactions of pilus components with other molecules. I am excited to be a part of this research and help advance our understanding of this opportunistic pathogen.
- How do you stay updated with the latest developments and techniques in structural biology?Sample Answer: I am committed to staying current with the rapidly evolving field of structural biology. I regularly read scientific journals and attend conferences and seminars related to structural biology and related fields. I am an active member of online forums and professional networks where researchers share the latest discoveries and techniques. Additionally, I actively engage in hands-on training sessions and workshops to gain proficiency in new experimental methods and software tools. Continuous learning and staying informed about emerging trends are essential in the field of structural biology.
- Can you describe your experience with collaborative research and communication skills?Sample Answer: Collaboration is a vital aspect of scientific research. In my previous roles, I have had the opportunity to work with multidisciplinary teams, including biologists, chemists, and computational scientists. Effective communication is crucial in these collaborations, and I have honed my skills in both oral and written communication. I regularly presented my research findings at lab meetings and conferences and have published my work in peer-reviewed journals. I believe in clear and concise communication to facilitate productive teamwork and the dissemination of research findings.
All the best!
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