JRF position at IIT Bombay

JRF Position at IIT Bombay – MSc Biotech & Biochem Apply Online

JRF Position at IIT Bombay – MSc Biotech & Biochem Apply Online. IIT Bombay MSc Biotech job. MSc Biochemistry jobs at IIT Bombay. Interested and eligible applicants can check out all of the details on the same below:

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INDIAN INSTITUTE OF TECHNOLOGY BOMBAY
POWAI, MUMBAI 400076.

Advertisement No.: IRCC/EXT338/2023

Job Title : Junior Research Fellow

Job Reference Number : 50502371

Application End Date : 20.09.2023

Type of Employment : Proj. Staff Contract

No. of Position(s) : 01

IITB Project Recruitment:

Project title : Liquid-liquid phase separation of α-Synuclein leading to amyloid fibril formation: Implications in Parkinson’s disease pathology

About the project:

  • Liquid-liquid phase separation (LLPS) is an important phenomenon for explaining the formation of membrane-less organelles in cells.
  • Recent studies also suggested that LLPS is also responsible for amyloid fibril nucleation associated with various neurodegenerative diseases such as Alzheimer’s, Parkinson’s and frontotemporal dementia.
  • This DST project studies alpha-synuclein protein (which aggregates and kills dopaminergic neurons in Parkinson’s disease) phase separation in vitro and inside the neuronal cells.

Essential Qualifications & Experience: MSc (Chemistry, Biochemistry and Biotechnology) through a process described

through any one of the following:

  • Scholars who are selected through National Eligibility Tests – CSIR-UGC NET including lectureship (Assistant Professorship) and GATE.
  • The selection process through National level examinations conducted by Central Government Departments and their Agencies and Institutions such as DST, DBT, DAE, DOS, DRDO, MHRD, ICAR, ICMR, IIT, IISc, IISER etc.
  • Candidate with first class is preferred. Also candidate with hands on experience in protein chemistry and cell biology will be given preference.

Job Profile : Protein expression and purification, Cell biology experiment, cloning and biophysical studies

Pay Details : Consolidated salary Rs.31000/- p.m. + HRA

General information :

  • The position is temporary for a period of 1 year and tenable only for the duration of the project.
  • The appointment is for time bound project and the candidate is required to work mainly for the successful completion of the project. The selection committee may offer lower or higher designation and lower or higher salary depending upon the experience and performance of the candidate in the interview.
  • Candidates called for interview will be required to attend at his/ her own expenses.
  • For any queries/clarification please contact: [email protected]

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Here are some potential interview questions and answers for the JRF position at IIT Bombay:

1. Can you briefly explain your educational background and any relevant qualifications or certifications you hold?

Answer: I hold an MSc degree in Biotechnology. I completed my degree with a first-class distinction, which reflects my strong academic background in the field. Additionally, I have hands-on experience in both protein chemistry and cell biology, which aligns well with the requirements of this role.

2. Could you describe your familiarity with Liquid-Liquid Phase Separation (LLPS) and its significance in cell biology and neurodegenerative diseases like Parkinson’s?

Answer: Liquid-liquid phase separation (LLPS) is a fundamental phenomenon in cell biology, responsible for the formation of membrane-less organelles. LLPS has gained significant attention due to its role in the nucleation of amyloid fibrils associated with neurodegenerative diseases, including Parkinson’s. I am familiar with LLPS and understand its importance in the context of this research project. My academic background in biotechnology has provided me with a solid foundation in these concepts.

3. Can you share your experience with protein expression and purification techniques?

Answer: I have practical experience in protein expression and purification techniques gained through both coursework and laboratory work during my MSc program. I have successfully expressed and purified various proteins for different research projects. These experiences have equipped me with the necessary skills to contribute effectively to the protein-related aspects of this project.

4. Could you explain your understanding of the role of α-Synuclein in Parkinson’s disease and how this project aims to investigate it?

Answer: α-Synuclein is a key protein associated with Parkinson’s disease, known for its aggregation and its impact on dopaminergic neurons. This project aims to study the liquid-liquid phase separation of α-Synuclein both in vitro and inside neuronal cells. By doing so, we hope to gain insights into how LLPS contributes to the formation of amyloid fibrils in Parkinson’s disease, ultimately advancing our understanding of the disease pathology.

5. What motivates you to apply for this Junior Research Fellow position at IIT Bombay and how do your qualifications and experiences align with the requirements of the role?

Answer: I am motivated to apply for this position because it offers an excellent opportunity to contribute to cutting-edge research in the field of neurodegenerative diseases, particularly Parkinson’s disease. My educational background in biotechnology, coupled with my experience in protein chemistry and cell biology, aligns perfectly with the job requirements. I am excited about the prospect of working on a DST project that could potentially have a significant impact on our understanding of Parkinson’s disease pathology.

ALL THE BEST!

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