Study shows: T cells more important than antibodies in COVID-19
Researchers around the world are working day-and-night to understand the SARS-CoV-2 virus as well as to discover a possible treatment for it, as the novel coronavirus continues to infect thousands of individuals globally.
Some of the recent research studies on COVID-19.
T cells play a more critical role in battling coronavirus
According to a new study, a type of WBC referred to as T cells take the lead in shielding the body from COVID-19 infection, playing a much important role than antibodies.
The results of the study are published in the journal Cell. The study suggests that to ensure immunity against COVID-19, vaccine prospects should aim to evoke a broad immune response that includes antibodies and T cells.
The research likewise directs at why older COVID-19 patients are far more susceptible to the infection. Scientists from La Jolla Institute for Immunology in the United States, who did the research, have described that with increasing age, a body’s immune action becomes less coordinated and the reservoir of T cells declines.
This research might describe why older individuals are more vulnerable to severe or deadly COVID-19 infection.
The scientist collected blood samples from 50 COVID-19 infected individuals and analyzed antibodies and T cells specific to the SARS-CoV-2 virus.
The outcomes of the study revealed that a strong SARS-CoV-2 specific T cell response was predictive of milder infection, showing that T cells are more crucial in the body’s fight against this infection.
Conditions associated with obesity makes individuals a lot more prone to COVID
According to a study that might discuss why obese individuals are most likely to die from COVID-19, conditions associated with obesity like inflammation and leaky gut leave an individual’s lungs more susceptible to COVID-19.
The results of this research are released in the journal eLife. The study reveals that drugs used to lower inflammation in the lungs can be beneficial to obese individuals with coronavirus infection.
The mechanism behind why obesity contributes to severe infection was unidentified, while a number of previous studies have actually revealed correlations between obesity and COVID-19.
The new research now suggests that one factor behind the raised risk is that fat has high quantities of ACE2 receptors, which are entry points for the SARS-CoV-2 virus on host cells. However, the study notes that disease severity is much more linked to the conditions associated with obesity.
A higher overall inflammatory condition, which compromises the response of lung tissues to infection, is accompanied by obesity. ‘Leaky gut’ — a condition where cell lining develops gaps, allowing small amounts of intestinal contents to spill into the bloodstream, is an additional problem that makes obese people susceptible to COVID-19.
Covid might end up being a seasonal infection
Accoring to another study, COVID-19 is likely to become a seasonal infection in countries with temperate climates even after herd immunity is achieved.
The findings of the study are published in Frontiers in Public Health. The value of public health measures required to control the virus is highlighted in the research.
As per the research, people will certainly need to learn to live with COVID-19 and proceed to practice the best prevention steps, like using masks, physical distancing, hand hygiene, as well as avoid crowded places.
Lots of respiratory viruses comply with seasonal patterns, such as influenza, as well as several types of coronaviruses trigger common cold. These are known to peak in winter months in temperate areas; however, it will circulate year-round in tropical areas.
The research reveals that any type of virus’s survival in the air and on surfaces, individuals’ vulnerability to it, and social practices, such as indoor crowding, differ throughout various seasons because of modifications in temperature. At different times of the year, these aspects affect the transmission of respiratory viruses.
But, the aspects controlling the seasonality of viruses can not yet halt its spread in the summer, as COVID-19 has a higher transmission rate.
The transmission rate will certainly drop substantially once herd immunity is achieved, making the infection much more prone to seasonal aspects.
Re-hospitalisation likey required for patients with high temperature, and low oxygen
According to a research study in the United States, COVID-19 patients who come to the hospital with low oximeter analyses or high temperatures are more likely to return within a week of their discharge.
According to data from the March to May from a region in Philadelphia has revealed that approximately 1 in 10 people identified with COVID-19 required to return to a health center after discharge from the hospital.
The results of the research id released in Academic Emergency Medicine. The study gives new insights for medical professionals to battle this pandemic.
The research was carried out in 1,419 people who went to an emergency department between 1 March and 28 May, were discharged from the hospital, and again tested positive for COVID-19 infection within 7 days.
Patients over 60 were more than 5 times as most likely to need hospitalization after being released from their first visit when compared to patients the age of 18-39 years.
Additionally, the research revealed that patients of any age group with low pulse oximetry readings were about 4 times as likely to need re-hospitalization as compared to those with higher analyses pulse oximetry readings. Compared to the people without fever, those with high temperatures were more than 3 times likely to return to a healthcare facility.
Author: Sruthi S