Scientists discover three distinct immune system pattern in severe COVID-19 patients
Distinct immune profiles or “immunotypes” have determined by the scientists studying the immune responses of 125 hospitalized COVID-19 patients. The scientist also revealed an advancement that might help in the development of new treatments against COVID-19 – how these were linked to disease severity.
The study on the ‘three distinct immune system patterns in severe COVID-19 patients’ is released in the journal Science. As per the research, whether there is a usual profile of immune dysfunction in seriously ill COVID-19 individuals continues to be unidentified. The scientists including Divij Mathew, the University of Pennsylvania, the United States said that by localizing patients on an immune topology map, we can start to infer which kinds of therapeutic interventions might be most helpful in specific individuals. Until now, the scientist claimed that the studies investigating this are limited, reporting on small cohorts or single patient.
The scientists stated that, as the worldwide COVID-19 pandemic continues, researchers around the world continue to study the characteristics of the human immune reaction in combating the disease. Mathew as well as his colleagues examined the cells of the immune system in 125 COVID-19 patients at2 points throughout their first week of hospital stay to expand on findings reported so far, and to better connect immune features in COVID-19 people with clinical features of the disease.
The scientists stated that to analyze the patient immune cells they used an approach called flow cytometry, which is a method used to detect and determine the physical and chemical characteristics of a populace of cells. They stated the research study likewise gathered clinical information on the patient cohort.
The research reported numerous vital findings by integrating the clinical and flow cytometric data, the findings also included a specifying function of COVID-19 in this group is variability in their own immune response. The study also noted that specific stable immune reaction signatures in subsets of their patients, which changed consistently over time.
Many of these patterns, were linked with even worse disease end results – like impaired activation of a part of the immune system called the CD8 T cells, as per the scientists. The researchers specified 3 of these immune response signatures, or immunotypes, associated with the improving health of the patients versus patients having poor clinical trajectories.
The scientists said that these immunotypes might show significant distinctions in the ways patients respond to COVID-19. They presume that their research will provoke the idea of developing future immune-based clinical trials or clinical treatments to people whose immunotype offers better potential advantages.
Author: Sruthi S