Blood Test For Brain Cancer
Brain cancer remains difficult to diagnose, due to nonspecific symptoms and a lack of cost-effective tests.
A new blood test that uses a technique called an attenuated total reflection (ATR)-Fourier transform infrared (FTIR) spectroscopy, in conjunction with machine learning technology, may help advance the detection of brain cancer.
The patented technology applies artificial intelligence to check for the signs of cancer. A team developed this new technology at the University of Strathclyde. It uses infrared light to produce a “bio-signature” of a blood sample.
In the research paper, the scientists describe the development of instrumentation for the analysis of serum that can differentiate cancer and control patients at a sensitivity and specificity of 93.2% and 92.8%, respectively. Besides, preliminary clinical data from the first prospective clinical validation study are presented.
This research is advancing towards clinical translation and is being commercialized by ClinSpec Diagnostics.
Matthew J. Baker, Ph.D., reader in Strathclyde’s department of pure and applied chemistry and CSO with ClinSpec Diagnostics, said that the published clinical data propose that the blood test works in a clinical setting. Earlier detection of brain tumors in the diagnostic pathway brings the potential to improve patient quality of life and survival significantly. Consequently, this also leads to providing savings to health services.
Holly Butler, Ph.D., research and development director with ClinSpec Diagnostics, said that the New Blood Test for Brain Cancer would provide patients with rapid access to diagnosis and treatment.
Paul Brennan, Ph.D., senior clinical lecturer and consultant neurosurgeon at the University of Edinburgh, said that Diagnosing brain tumors is challenging, leading to delays and frustration for lots of patients. The problem is that symptoms of brain tumors are nonspecific, such as headache or memory problems. It can be difficult for doctors to tell which people are most likely to have a brain tumor. The New Blood Test for Brain Cancer provides more rapid diagnosis for people with a brain tumor and quicker access to treatment.
The Brain Tumour Charity ambassador Hayley Smith is backing this research. She added that it is very encouraging to hear that this blood test can lead to quicker diagnosis of brain cancer. This kind of analysis will be vital to patients, helping people to get the correct diagnosis quicker. This ultimately will help people to get the urgent medical care that they need.
Patients with brain cancer frequently present with nonspecific symptoms, and the final cancer diagnosis can be time-consuming. The scientists have analyzed samples from a prospective group of 104 patients, and they found that the blood test could distinguish patients with brain cancer from healthy individuals with 87% accuracy.
While the proposed system -Blood Test For Brain Cancer- does not offer a thorough diagnosis, it could play a significant role in the diagnostic process as a triage tool.