Indian Researchers Discover Potential Drugs Against Tuberculosis
Tuberculosis, caused by the bacteria Mycobacterium tuberculosis, is a major cause of death worldwide and to lessen this death count Researchers have now come with a new drug candidate to fight tuberculosis. In 2017 alone, 10 million individuals around the globe were impacted by the disorder, and about 1.6 million succumbed to it.
In recent a recent study, researchers from the Veer Narmad South Gujarat University have developed some potential drugs against tuberculosis and have analyzed their efficiency against the TB bacteria and other germs.
Scientists throughout the globe are exploring TB therapy options using natural chemicals, and mixtures of drugs, and are screening new drugs using computer-based approaches. In the current study, the investigators have synthesized some agents belonging to the group’azoles’, which are proven to kill germs fungi, by preventing the synthesis of lipids in their own body. The analysis has been published in the journal Current Computer-Aided Drug Design. The researchers then analyzed the efficiency of the compounds against four other germs, the TB germs, and three species. They have decided that the concentration of those chemicals that can inhibit the growth of microbes. Using a computer-based approach called they studied the interaction of these compounds with a target protein in the TB bacteria. They also analyzed the absorption, distribution, metabolism, and excretion properties of these compounds.
Six of the synthesized compounds showed promising antimicrobial activity with one of them being very efficient in killing the TB bacteria were found by the Researchers.
The Researchers said that this compound could act as a potential anti-tuberculosis drug in the future. The also said give the best option for the preparation of new derivatives to be able to enhance antitubercular activity in future with more improved potency.
With a global fight against tuberculosis on full throttle, studies like this can help us reach the objective of eliminating the disease very soon.