Novel Protein Sequencing Method Discovered at University of Texas
A group of researchers at The University of Texas, Austin has shown a method to sequence proteins that’s a lot more sensitive & effective in identifying protein molecules as opposed to requiring countless molecules at a time used in current protein sequencing technology. The progress could have a significant impact on research, which makes it more easy to reveal novel biomarkers, in addition, to enhance our comprehension of how cells operate. The findings of this research study were published in Nature Biotechnology Journal.
Currently, Mass spectrometry is being used as a standard method worldwide as a tool for sequencing of proteins. But the results for the same turn out to be less sensitive & reliable for most of the applications. The biggest drawback is it can detect a protein only in presence of million copies of it.
The new technology provides for comprehensive and rapid information about tens of thousands of proteins which play a role in diseases or in healthy functioning. In disorders–such as diabetes, Alzheimer’s, Heart Attacks the cells produce proteins and other substances that act as biomarkers that are unique. A better discovery of these biomarkers would help researchers provide more accurate diagnoses for patients, earlier or understand the causes of ailments.
Researchers at the University of Texas believe that with this new method, called single molecule fluorosequencing, one can sequence millions of individual protein molecules simultaneously in one sample. The Novel protein sequencing method has a high throughput and a greater sensitivity than existing protein sequencing technology.