--Sharing is Caring--

Scientists For The First Time Synthesize Deadly Artificial Prions

For the first time in the science history, scientists at Case Western Reserve University of Medicine (CWRU) have created artificial human prions with the aim to develop a cure for common brain disorders.

Prions are deadly brain proteins that cause devastating infections in the brain. When they bind to normal proteins, they can create a terrifying domino effect that prods millions of minuscule holes in the brain resulting in genetic brain disorders and fatal damage.

Microscopic image of synthetic human prions accumulating in the brain of a mouse that was genetically altered to produce a certain human protein. Image: Case Western Reserve School of Medicine

A common brain disorder associated with prions is the Creutzfeldt-Jakob disease (CJD) which generally affects at least one in a million people around the globe.

According to Jiri G. Safar, a neurologist at CWRU, the clones were formed through a series of test tube processes and using more advanced biophysical tools. Dr. Safar is hopeful that through this breakthrough, scientists will understand the replication of human prions and develop a certain drug that can inhibit their activity in the brain.

During the experimentation process, the synthetic human prions were tested to transgenic mice and resulted in neurological dysfunction. The first deaths occurred after 459 and the second occurred after 224 days.

There were already previous studies before using animal prions. However, they were not as conclusive and effective as compared to using human prions. The animal prions generally have a different structure and their replication process does not apply to humans.

Recommended for you:
Biotecnika Times - Newsletter 13.12.2018 - Ramalingaswami Fellowship, Top 10 Biotech Scholar

“With the production of synthetic human prions, researchers can finally engage in a feature-for-feature comparison”, says Dr. Safar. “The discovery will also open the door to a higher possibility of discovering a cure for Alzheimer’s disease and Parkinson’s disease considering that they spread through the brain in a similar way as CJD.”

--See Also--
Previous articleUGC-DSA-SAP Project Fellow Position Vacant @ Anna University
Next articleResearch Positions Vacant for MSc Biosciences Candidates @ ICAR-NBAIM
Perfection is her hobby, Reliability is a synonym, Editing is her passion, Excellence is her Goal, Tactfulness is in her genes, Yellow is her Fav color. Preety Suman is the name of the Professional on whom entire BioTecNika relies when it comes to its website.A Gold Medalist in Biotech from SRM University, Chennai with a 9.9 CGPA ( was awarded the Gold Medal by Honorable Prime Minister of India Shri Narendra Modi , as seen in the pic ), She decided to join forces with BioTecNika to ensure India's largest BioSciences Portal expands its reach to every city in India.She has redesigned the new avatar of BioTecNika from scratch and heads the most dynamic, vibrant and well informed Online Team at Biotecnika Info Labs Pvt Ltd