Syngene Biological Sciences Research Associate Invitro Job, Apply Online
Syngene Biological Sciences Research Associate Invitro Job, Apply Online. MSc Biological Sciences Job in Syngene, Bangalore. Syngene is hiring Biological Sciences candidates for Senior Research Associate – Invitro ADME + Bioanalytical job.
The five possible interview questions that can be asked in the technical round for Senior Research Associate – Invitro ADME + Bioanalytical position, along with their answers are posted below:
Job Title: Senior Research Associate – Invitro ADME + Bioanalytical
Job ID: 53989
Job Location: Hyderabad
Reporting to: Senior Principal Scientist
Job Grade: 9-II
About Syngene: Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply.
At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and SOPs, in letter and spirit.
Mandatory expectation for all roles as per Syngene safety guidelines
- Overall adherence to safe practices and procedures of oneself and the teams aligned.
- Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards.
- Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
- Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
- Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
- Compliance to Syngene’ s quality standards at all times.
Core Purpose of the Role:
- Bioanalytical scientist familiar in handling HPLC and support ADME screening assays: Formulations analysis, solubility studies, stability studies, ectc. and understanding of LCMS in line with business needs.
Key Responsibilities:
- Optimization of test compounds and to develop high throughput, fit for purpose HPLC-UV methods to support ADME samples analysis: Formulations analysis, solubility studies, stability studies, etc.
- Perform analysis of samples generated for the screening of compounds for ADME assays and Processing of different matrices/formulation samples of PK studies
- Good written and oral communication skills interacting with internal stakeholders
- Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system
- Preparation of protocols, reports and templates for responsible activities
- Instrument maintenance, calibration and maintaining documentation as per regulatory requirements and company policy
- Understanding and demonstrating responsibility for safety of self & colleagues by following all safety protocols provided by Syngene
- Adherence to all environment, health, and safety (EHS) policies & standards at all times in the workplace
- Wearing all PPE as required.
- Adherence to all procedures related to Syngene’s data integrity policies
- Compliance to Syngene’s quality standards at all times.
Syngene Values: All employees will consistently demonstrate alignment with our core values
- Excellence
- Integrity
- Professionalism
Experience:
- Minimum 2 to 4 years of relevant industrial experience
Technical/Functional Skills:
- Hands-on experience in handling of LC-MS/MS systems is mandatory and experience on HRMS is advantageous
- Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction
- Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assay samples analysis.
- Basic knowledge on Large molecule and Peptides analysis using LCMS/HRMS
- Should assist/deliver the scientific presentation in departmental journal club and write official Project reports
- Should be equipped with quality policies related to data management and data integrity
Behavioural Skills:
- Demonstrate ability to be a team player.
- Commitment to deliver the study reports within the agreed timelines
- Adaptability to changes in the dynamic lab environment
- Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals
Educational Qualification: A M Pharm. in any pharmaceutical science or M Sc. in biological science.
Equal Opportunity Employer:
It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.
Here are five possible interview questions that can be asked in the technical round for Senior Research Associate – Invitro ADME + Bioanalytical position, along with their answers:
- Can you describe your experience in developing and optimizing HPLC-UV methods for ADME samples analysis, including formulations analysis, solubility studies, and stability studies? How have you ensured that the methods are fit for purpose and high throughput?
Answer: In my previous role, I have developed and optimized HPLC-UV methods for ADME samples analysis. This involved understanding the requirements of the assays, such as formulations analysis, solubility studies, and stability studies, and designing methods that are fit for purpose and capable of handling high throughput samples. I focused on parameters like column selection, mobile phase selection, and sample processing techniques such as protein precipitation, liquid-liquid extraction, and solid phase extraction. By systematically optimizing these factors, I ensured the methods were efficient, reliable, and suitable for the intended analysis.
- How would you approach troubleshooting issues with HPLC/LC-MS/MS systems? Can you provide an example of a technical problem you encountered and successfully resolved?
Answer: Troubleshooting HPLC/LC-MS/MS systems requires a systematic approach. Firstly, I would review the system setup, ensuring that all components are functioning properly and are appropriately calibrated. I would then check the chromatographic conditions, such as column condition, mobile phase composition, and gradient program. If the issue persists, I would evaluate the sample preparation techniques and assess the quality of the samples. Finally, I would verify the instrument settings and parameters. In a previous project, I encountered a problem with inconsistent peak shapes in the chromatograms. Through a step-by-step troubleshooting process, I identified and resolved the issue by adjusting the mobile phase composition and optimizing the injection volume.
- How have you ensured compliance with regulatory requirements and company policies in terms of documentation and data integrity? Can you provide an example of how you maintained documentation for regulatory purposes?
Answer: Compliance with regulatory requirements and data integrity policies is crucial in my work. I ensure documentation is maintained as per regulatory guidelines and company policies by following standard operating procedures (SOPs), recording all relevant information in lab notebooks, and accurately completing protocols, reports, and templates. I also adhere to data integrity policies by maintaining data traceability, recording any changes or corrections appropriately, and storing data securely. For instance, in a recent project, I prepared a protocol for a study, carefully documented all experimental details, results, and observations, and ensured the documentation was complete and in line with regulatory requirements.
- How do you prioritize and manage your work to deliver study reports within agreed timelines? Can you provide an example of a situation where you successfully met a challenging deadline?
Answer: To prioritize and manage my work effectively, I create a detailed project plan, breaking down tasks and setting realistic timelines for each stage. I regularly assess progress and make adjustments if necessary. I also ensure open and transparent communication with team members and stakeholders to address any potential bottlenecks or delays. In a recent project, we had a challenging deadline to deliver a comprehensive study report. To meet the timeline, I collaborated closely with the team, delegated tasks efficiently, and maintained a proactive approach. Through effective planning and coordination, we successfully completed the project and delivered the study report on time.
- Can you provide an example of your experience in presenting scientific findings in a departmental journal club or similar settings? How do you communicate technical information confidently and effectively?
Answer: I have actively participated in departmental journal clubs and presented scientific findings to colleagues and collaborators. When communicating technical information, I focus on structuring my presentation in a clear and concise manner, ensuring key points are emphasized. I use visual aids such as slides to support my presentation and provide visual references
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