JNCASR Biological Sciences Project Job Opening, Applications Invited
JNCASR Biological Sciences Project Job Opening, Applications Invited. R&D position at JNCASR. JNCASR Research jobs for MSc candidates. Interested and eligible applicants can check out all of the details on the same below
Hey there, looking for some help with what kind of possible interview questions can be asked for the role of Project Assistant at JNCASR? Then check them out below
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Jawaharlal Nehru Centre for Advanced Scientific Research
(An Autonomous Institute under Dept. of Science & Technology, Govt. of India – A Deemed University)
Jakkur Post, Bengaluru – 560 064, INDIA
Advt. No.ICMS/SR-EMR/01
Applications are invited for the temporary position of Project Assistant to work on “Small-Molecule Autophagy Modulators for Treating Neurodegenerative and Neurodevelopmental Disorders” under the Principal Investigator Prof. Sridhar Rajaram, International Centre for Materials Science, JNCASR, Jakkur, Bengaluru 560 064.
The project involves the synthesis of a library of small molecule autophagy modulators and testing them in autophagy assays.
Name of the Post – Project Assistant
No. of Posts – 02
How to Apply –
Interested candidates are required to send a scanned copy of the duly filled-in Template/Application form (available
on the website) along with scan copies of original testimonials in support of educational qualification, age, experience, publication, etc with a brief resume to Prof. Sridhar Rajaram, International Centre for Materials Science through email [email protected] latest by May 22, 2023.Note:
- Candidates are required to provide their Skype ID, email address and mobile number.
- Shortlisted candidates may be invited for an online interview
Essential Qualification: M.Sc in Chemistry or Biological Sciences
Desirable Qualification: Preference will be given to JRF
Remuneration – Project Assistant (Remuneration Rs.25,000/- (Without NET/GATE etc), Rs.31,000/- (With NET/GATE etc) plus 24% HRA
Click here to download the application format
Check the notification below
- Can you explain your experience and knowledge in the synthesis of small molecules for autophagy modulation? How would you approach designing and synthesizing a library of small molecule autophagy modulators? Answer: I have a strong background in organic chemistry and experience in designing and synthesizing small molecules. For this project, I would start by analyzing the target autophagy pathway and identifying key molecular targets. Then, I would utilize various synthetic techniques to develop a diverse library of small molecules that can modulate autophagy. I would also employ structure-activity relationship (SAR) studies to optimize the potency and selectivity of the modulators.
- Have you worked with autophagy assays before? Can you describe your experience in conducting autophagy assays and interpreting the results? Answer: Yes, I have previous experience in performing autophagy assays. I am familiar with techniques such as fluorescence microscopy, western blotting, and flow cytometry to assess autophagic flux and measure the levels of autophagy-related proteins. I also have knowledge of using specific markers such as LC3-II and p62 to monitor autophagosome formation and degradation. Interpretation of the assay results involves analyzing changes in autophagy markers and comparing them to control conditions.
- How would you prioritize and manage your tasks in a time-sensitive project like this? Can you provide an example from your previous experience? Answer: In a time-sensitive project, I would prioritize tasks based on their criticality and dependencies. I would create a detailed project plan, breaking down the tasks into smaller milestones and setting deadlines for each. Effective communication with the team members and the principal investigator is crucial to ensure smooth progress. An example from my previous experience is when I successfully managed a similar time-sensitive project by regularly monitoring the progress, adapting the plan when necessary, and effectively coordinating with team members to meet deadlines.
- What are some challenges you might anticipate in synthesizing and testing a library of small molecule autophagy modulators? How would you address these challenges? Answer: One challenge could be obtaining high yields and purities of the synthesized molecules. To overcome this, I would optimize reaction conditions, purification techniques, and characterization methods. Another challenge could be limited availability of certain starting materials or reagents. In such cases, I would explore alternative synthetic routes or collaborate with other research groups to acquire the required materials. Additionally, ensuring the reliability and reproducibility of the autophagy assays can be challenging. I would implement rigorous quality controls, replicate experiments, and validate the results using different assays or techniques.
- Can you discuss the potential implications and significance of developing small molecule autophagy modulators for treating neurodegenerative and neurodevelopmental disorders? Answer: Developing small molecule autophagy modulators has significant implications for the treatment of neurodegenerative and neurodevelopmental disorders. Autophagy plays a crucial role in maintaining cellular homeostasis and clearing damaged proteins and organelles. Dysregulation of autophagy has been implicated in various neurological disorders. By modulating autophagy, we can potentially enhance the clearance of toxic aggregates, reduce neuronal damage, and promote cell survival. Small molecule modulators offer a targeted and potentially more accessible therapeutic approach compared to other interventions. This research has the potential to contribute to the development of novel treatment strategies for these disorders.
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