Immunosuppressive Cells Critical for Control of Inflammation in Newborns
Myeloid-derived suppressor cells (MDSCs) are pathologically activated and relatively immature myeloid cells that have been implicated in the immunological regulation of many pathologic conditions. In healthy adults, these cells are rarely detected but accumulate during certain pathological conditions, altering the immune response to cancer and chronic infection and promoting tumor progression.
“Our research sheds light on the function of MDSCs in newborns, suggesting that they are critical for the regulation of inflammation during the first weeks of life,” said Dmitry I. Gabrilovich, M.D., Ph.D., Christopher M. Davis Professor and program leader of the Immunology, Microenvironment and Metastasis Program at the Wistar Institute. “We also revealed a physiological role of MDSCs expansion, which was widely considered to be driven by pathological conditions or pregnancy, broadening the importance of MDSCs in the immune system.”
This new study by researchers at the Wistar Institute in collaboration with Sun Yat-sen University in China, characterizes the transitory presence of MDSCs and demonstrates how they play a critical role in regulation of inflammation in the early stages of life.
The researchers analyzed the transcription profile of MDSCs from newborn mice, and observed that an increase in the expression
of genes that are critical for the immunosuppressive functions of these cells. Mechanistically, they demonstrated that the accumulation of MDSCs is linked with milk feeding, as it depends on lactoferrin, a milk component with potent immunoregulatory activity, which can induce upregulation of these genes.Additionally, the study found that MDSCs are important for the control of inflammation in newborns. In fact, human newborns with normal birth weight had significantly higher proportion of MDSCs and higher immunosuppressive activity compared with adults as well as infants with low birth weight. These infants are at a higher risk for development of pathological inflammatory conditions, such as necrotizing enterocolitis, a condition that causes inflammation of the intestine and may put the infant at risk for developing potentially life-threatening infections.
“Our findings demonstrate that MDSCs reduce inflammation and increase survival in a model of necrotizing enterocolitis, thus suggesting that MDSCs not only can be present in healthy individuals but also could be an important protection mechanism evolved in response to the microbial colonization of the gut that takes place during the first days of life,” said Gabrilovich.
“Based on our data, MDSCs may be used as a potential therapeutic target for treating necrotizing enterocolitis and other inflammatory conditions in infants,” said Michela Perego, Ph.D., an associate staff scientist in the Gabrilovich Lab and co-first author of the study. “Our finding that accumulation of MDSCs depends on lactoferrin may also provide a rationale as to why feeding infants human milk versus formula has been shown to reduce the risk of necrotizing enterocolitis.”
