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inStem Latest Jobs Bangalore

Government MSc Life Sciences & PhD Biochemistry/Structural Biology Research Scientist Vacancies at inStem, Bengaluru. inStem is hiring msc life sciences & phd biosciences candidates for Research Scientist vacancies.. inStem is hiring msc & phd candidates. Interested and eligible candidates check out all of the details on the same below:

Post I

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Team Lead/Senior Research Scientist

KNOWLEDGE, EXPERIENCE AND SKILLS:

  • Ph.D. in structural biology (x-ray crystallography) or related field is needed
  • Minimum of 4 years of academic/industry experience with a record of significant contributions to development of project is required
  • Recognized scientific experience in structural biology along with peer-reviewed publications is required
  • Strong record of success in employing Structure-Based Drug Design (SBDD) and Fragment-Based Lead Discovery (FBLD/FBDD) approaches using x-ray crystallography are demanded
  • Broad drug discovery background, with knowledge of biophysics, biochemistry, and protein sciences are required
  • Outstanding leadership capacities
  • Experience in working with external research organizations, such as contract research organizations, and/or public-private consortia is favored
  • Experience in scientific programming (Unix shells, Python, Perl), and capability to work with the Most Recent applicable software packages and at a mixed Linux/Windows computational environment is favored

DUTIES AND JOB FUNCTIONS:

  • Guarantee timeliness and precision of the results and also of written reports. Organize and prioritize work done in the lab
  • Expedite the completion of projects and make sure that appropriate turn-around goals are met. Perform troubleshooting of problems with processes, protocols and methods in all aspects of structural and molecular biology
  • Monitor and ensure that proper processes of protein crystallography are followed closely for quality control and quality assurance and proper documentation is logged in
  • Give presentations to the group members in Addition to at educational workshops of this department
  • Support protein design, purification and expression to support small-molecule discovery
  • Biophysical characterization of proteins and protein-ligand complexes to facilitate protein crystallization and protein science studies (e.g. DLS, ITC, DSC, fluorescence, NMR)
  • Design of protein constructs for both SBDD and protein sciences experiments
  • Lead conclusion of high quality protein structures and co-crystal structures throughout crystallization, data collection and refinement
  • Communicating effectively with medicinal and computational chemists to translate hit to leads
  • Familiarity with up-to-date lab safety protocols and employ them in the course of all work
  • Assist senior researchers in executing, conducting analysis and reporting results
  • Familiarity with literature and internal best practices to identify opportunities to enhance productivity and quality of work
  • Participate in research discussions with members of their research teams in a highly collaborative research environment
  • Understanding of X-ray data collection and structure determination methods
  • Experience of high throughput structural methods
  • Experience with automated systems, such as crystallization plate setup and crystal imaging robotics
  • Works relatively independently on assigned tasks
See Also
ICMR-NIMR COVID-19 Staff Recruitment With Rs. 51,000 pm Salary

Post II

Research Scientist/Postdoctoral Fellow:

KNOWLEDGE, EXPERIENCE AND SKILLS:

  • A recent PhD in Structural Biology or Biochemistry or a related discipline, with an established history in macromolecular crystallography.
  • Hands-on expertise in cloning, recombinant protein expression and purification
  • Experience in solving protein structure by crystallization, X-ray diffraction and relevant tools. Expertise in structure-based drug design is valuable.
  • Expertise in drug binding studies with structure-activity relationship studies (SAR) and protein-protein interaction studies utilizing 1D NMR would be an advantage
  • Working understanding of tools like protein fermenter, FPLC, circular dichroism, isothermal calorimetry, dynamic light scattering, Surface Plasmon resonance etc

JOB DESCRIPTION:

  • In this position, you will coordinate with cell biologists, medicinal and computational chemists to comprehend the molecular nature of this protein-ligand and protein-drug interaction.
  • Perform cloning, protein expression and purification studies
  • Biophysical characterization of protein-ligand and protein-small molecule connections
  • Support and empower reproducible large protein purifications in quality and quantity Acceptable for X-ray crystallography
  • Routine data analysis, project updates, literature survey and demonstrations about the target(s)
  • Participate in a project team meeting and contribute to the projects intellectually

DUTIES AND JOB FUNCTIONS:

  • Guarantee timeliness and precision of the results and also of written reports. Organize and prioritize work done in the lab.
  • Expedite the completion of jobs and make sure that proper turn-around goals are satisfied. Perform troubleshooting of problems using processes, protocols and methods in all aspects of structural and molecular biology.
  • Monitor and ensure that proper processes of protein crystallography are followed for quality control and quality assurance and proper documentation is logged in.
  • Give presentations to the group members in addition to at educational workshops of this department.
  • Support protein design, purification and expression to encourage small-molecule discovery
  • Biophysical characterization of proteins and protein-ligand complexes to ease protein crystallization and protein science research (e.g. DLS, ITC, DSC, fluorescence, NMR)
  • Layout of protein constructs for both SBDD and protein sciences experiments
  • Lead conclusion of top excellent protein structures and co-crystal structures throughout crystallization, data collection and refinement
  • Communication effectively with medicinal and computational chemists to interpret success to direct
  • Familiarity with up-to-date lab safety protocols and employs them in the course of work.
  • Generation of experimental documentation such as coverage.
  • Careful experimentation and record keeping.
  • Assist with the organization and upkeep of the lab and its equipment.
  • Take part in research discussions with all members of the study teams in an extremely collaborative research environment.
See Also
Centre for Stem Cell Research (CSCR) Life Sciences Recruitment

Post III

Associate Research Scientist

KNOWLEDGE, EXPERIENCE AND SKILLS:

Master’s degree in the field of life sciences with 1-3 years of work experience
Substantial expertise in protein chemistry via cloning, recombinant protein expression, purification and crystallization Is Vital

JOB DESCRIPTION:

  • In this place, you may concentrate on cloning, expression, purification and characterization of hard recombinant proteins. Position requires a coordinated effort by screening and structural biology to elucidate the molecular nature of this protein-ligand and protein-drug interaction.
  • Hands on experience in cloning, recombinant protein expression and purification
  • Coordinate cross-departmental actions for its successful utilization of purified proteins
  • Provide support in biophysical characterization of protein-ligand and protein-small molecule interaction
  • Support and empower reproducible large protein purifications in quality and quantity Acceptable for X-ray crystallography
  • Regular data analysis, project updates, literature survey and presentations on the target
  • Take Part in project team meeting and also contribute to the projects intellectually
  • Expertise in crystallization and solving protein structure from X-ray diffraction and related tools are an advantage
  • Working understanding of instruments like protein fermenter, FPLC, circular dichroism, isothermal calorimetry, dynamic light scattering, Surface Plasmon resonance etc
  • Care of good lab practices in work environment

ESSENTIAL DUTIES AND JOB FUNCTIONS:

  • Working understanding of affinity purification, gel filtration, FPLC, AKTA, SPR along with isothermal calorimetry
  • Support protein design, purification and expression to support small-molecule discovery
  • Provide support towards the biophysical characterization of proteins and protein-ligand complexes to ease protein crystallization and nourishment science research
  • Ensure the regular supply of quality proteins for screening in Addition to structural biology efforts
  • Computer skills with extensive expertise in data management, information analysis and statistical analysis
    needs to be detail oriented, well organized, and possess strong communication skills
  • Excellent teamwork skills as well as the ability to work in a fast paced, multi-disciplinary environment
See Also
ICMR-NIMR PhD Programme Admission Jan 2021 : Applications Invited

How to Apply: Interested applicants can send in the following information by email to [email protected]

  • Curriculum Vitae (CV)
  • Publication list
  • Contact details of three professional referees
  • Specify”Structural Biology” and your designation in the subject line of your email

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