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Research Fellow Post @ University of Leeds | Post in Structural Cell Biology

This job expires in :

-969Days -19Hours -47Minutes -40Seconds


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About the University:

The University, established in 1904, is one of the largest higher education institutions in the UK. We are a world top 100 university and are renowned globally for the quality of our teaching and research.

The strength of our academic expertise combined with the breadth of disciplines we cover, provides a wealth of opportunities and has real impact on the world in cultural, economic and societal ways.

The University strives to achieve academic excellence within an ethical framework informed by our values of integrity, equality and inclusion, community and professionalism.

Name of the Position : Research Fellow in Structural Cell Biology

Location : Leeds – Main Campus

Faculty/Service : Faculty of Biological Sciences

School/Institute : School of Molecular & Cellular Biology / Astbury Centre for Structural Molecular Biology

Category : Research

Grade : Grade 7

Salary : £32,548 to £38,833 p.a.

Working Time : 100%

Post Type : Full Time

Contract Type : Fixed Term (for up to 5 years – due to funding)

Closing Date : Sunday 28 January 2018

Reference : FBSAS1021

Job Description:

Are you looking to apply your skills in Imaging and Cell Biology to gain a new molecular understanding of how amyloid aggregates disrupt cells and to help develop new routes to combat amyloid diseases?

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We are looking for an outstanding postdoctoral research fellow to join a Wellcome Trust-funded team that will investigate how proteins aggregate into amyloid fibrils and how aggregates kill cells. Ultimately the team will involve four post-doctoral researchers and will combine chemical biology, biochemistry, biophysics, structural biology, cell biology, and experiments in C. elegans to define the mechanisms underlying amyloid aggregates to form and the consequences for cells of aggregation. The successful applicant for this post will use imaging methods including cryo-electron tomography and super-resolution light microscopy, combined with cell biology experiments and use of C. elegans models of disease to define the mechanisms of amyloid aggregation in cells and in vivo and to elucidate the effects of treatment with newly discovered small molecules in a cellular context.

You will be based in the laboratories of Professor Sheena Radford and Professor Neil Ranson, and work closely with our collaborators Drs Eric Hewitt and Patricija van Oosten-Hawle, and other members of the amyloid team. You will have a PhD (or be close to completion) in Cell Biology, Biochemistry, Structural Biology or a related discipline. You will have extensive experience of using imaging methods and cell biology to elucidate biological mechanisms. Experience in cryo-electron microscopy/tomography would be a significant advantage, but training will be given to outstanding candidates lacking this experience.

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How to Apply:

Further information about the project and recent publications are available within the additional information document.

To explore the post further or for any queries you may have, please contact:

Professor Sheena E Radford, Astbury Professor of Biophysics

Tel: +44 (0)113 343 3170, email: [email protected]

Professor Neil A Ranson, Professor of Structural Molecular Biology

Tel: +44 (0)113 343 7065, email: [email protected]

Downloads: Candidate Brief Additional Information

Application Deadline : Sunday 28 January 2018

Apply Online

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