--Sharing is Caring--

Looking for a postdoctoral fellow and a project assistant

Project : Understanding the movement of mRNAs in and out of translation

Our research group started in September 2013 at Department of Biochemistry, IISc. As a
group we are excited about understanding the movements of mRNA between different functional states in cytoplasm. Research in our laboratory has been funded by the highly competitive Intermediate Fellowship from The Wellcome Trust/DBT India Alliance.

About the Project :

An mRNA can be a) translated b) degraded or c) stored in a translationally silent state in
cytoplasm. We are trying to understand the mechanistic basis of various mRNA fate decisions.

Movement of mRNA between these functional states plays an important role in various cellular processes such as Development, Learning, Memory, Ageing and Regeneration. It also plays a crucial role in disease conditions such as Cancer, Neurodegenerative disorders, Duchenne Muscular Dystrophy etc. Specifically deregulated and uncontrolled translation is considered to be a contributing factor to tumorigenesis.

We are interested in studying the regulation of proteins that reduce protein translation
known as translation repressors in Saccharomyces cerevisiae. These factors act mostly at the translation initiation step. We are specifically working on translation repressors that contain Arginine-Glycine-Glycine (RGG) motif. We started addressing the role of arginine methylation of RGG-motifs in regulation of repression activity. We have now observed that RGG-motif protein Scd6 gets arginine methylated in Hmt1-dependent manner. Using a combination of genetic, biochemical and imaging approaches we observe that arginine methylation promotes Scd6 repression activity by augmenting its interaction with translation initiation factor eIF4G. These results were published last year as first publication from our group in Nucleic Acids Research journal. In this research we have demonstrated for the first time that arginine methylation regulates fundamental cellular process of translation repression. It raises a very exciting possibility that arginine methylation could be a general modulator of global translation since RNA binding proteins constitute the largest group of arginine methylated proteins.

See Also
MSc Life Sciences SRF Position Available @ ICAR - NAARM

We are currently focusing on looking at the role of arginine methylation in regulating other
translation repressors. We are also exploring other modes of regulation of translation repressors.

How to Apply :

Incoming postdoc/project assistant can work on these exciting aspects or come with a plan to address a question of his/her interest within the purview of lab. You can reach us at

Purusharth I Rajyaguru, PhD
Assistant Professor
Wellcome Trust-DBT India Alliance Intermediate fellow
Lab# FE-16
Dept. of Biochemistry, New Biological Sciences Bldg.
Indian Institute of Science
C V Raman Road, Bangalore, Karnataka 560012
Office phone: +91-80-22932547
Lab phone – 91-80-2293 2547

View Main Notification Here

Perfection is her hobby, Reliability is a synonym, Editing is her passion, Excellence is her Goal, Tactfulness is in her genes, Yellow is her Fav color. Preety Suman is the name of the Professional on whom entire BioTecNika relies when it comes to its website.A Gold Medalist in Biotech from SRM University, Chennai with a 9.9 CGPA ( was awarded the Gold Medal by Honorable Prime Minister of India Shri Narendra Modi , as seen in the pic ), She decided to join forces with BioTecNika to ensure India's largest BioSciences Portal expands its reach to every city in India.She has redesigned the new avatar of BioTecNika from scratch and heads the most dynamic, vibrant and well informed Online Team at Biotecnika Info Labs Pvt Ltd


Comments are closed.