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Vacancy in the post of Postdoctoral Research Associate @ Dept. of Clinical Biochemistry, University of Cambridge

The Institute of Metabolic Science-Metabolic Research Laboratories (IMS-MRL)  including the MRC Metabolic Diseases Unit across also houses clinical facilities for diabetes, endocrinology and metabolism for Addenbrooke’s NHS Trust, and for the Medical Research Council Epidemiology University Unit. The Institute provides modern laboratory accommodation and state of the art research facilities.The University of Cambridge is one of the world’s oldest and most successful Universities, with an outstanding reputation for academic achievement and research. It was ranked first in the 2011 QS World University Rankings and its graduates have won more Nobel Prizes than any other university in the world. The University and the Colleges are linked in a complex historical relationship. The Colleges are self-governing, separate legal entities which appoint their own staff. They admit students, provide student accommodation and deliver small group teaching (supervisions). The University awards degrees and its faculties and departments provide lectures and seminars for students, determine the syllabi for teaching and conduct research.

Job title: Postdoctoral Research Associate

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Salary range: £28,982 to £37,768 p.a.

Location: University of Cambridge, Metabolic Research Laboratories, Level 4 Wellcome Trust-MRC Institute of Metabolic Science (Box 289), Cambridge Biomedical Campus, Cambridge, CB2 0QQ

Length of appointment: Until 31st May 2018 as determined by the funding from the Academy of Medical Sciences to undertake the work for the study modelling human regulation of feeding in culture

Role Summary:

The Wellcome Trust-MRC Institute of Metabolic Science (IMS) is a multi-disciplinary Institute, within the University of Cambridge Clinical School on the Addenbrooke’s Hospital Site of the Cambridge Biomedical Campus. The mission of the IMS is to undertake basic and translational research relevant to the understanding, prevention and treatment of diabetes, obesity and other related endocrine and metabolic disorders. There are close links other research Institutes in particular with the Cambridge Institute for Medical Research (CIMR) as there is considerable synergy between the experimental approaches used by researchers. The role holder will use human stem cell-based models to investigate the molecular and cellular basis of obesity. This role is based within the research group of Dr. Florian T. Merkle in IMS. If selected for this position, you will have the opportunity to use cutting edge-techniques in a novel model system to investigate the mechanistic basis of a major human disease.

Key Responsibilities:

  • To undertake research to investigate the molecular and cellular basis of obesity through the use of human stem cell-based models
  • To edit the genomes of human pluripotent stem cells to introduce candidate mutations and differentiate these edited cells into hypothalamic neuron types
  • To collect and analyse neuronal phenotype data using sequencing, biochemical assays and imaging systems
  • To present research work and data within the Institute, nationally and internationally and to prepare and submit research for publication in peer-reviewed journals.
  • To develop the research objective of the study of the molecular and cellular basis of obesity through the use of human stem cell-based models
  • To assist in providing instruction to graduate students and other members of the research team in the use of specialized techniques
  • To assist the Principal Investigator in the management of the laboratory and the preparation of proposals and applications to funding bodies

Education & qualifications:

PhD in neuroscience, genetics, cell biology or a related biological science discipline

Specialist knowledge & skills:
– Molecular biology including cloning and CRISPR/Cas9 technology
– Neurobiology including development, signal transduction, and chemical neurotransmission
– Tissue culture, particularly of neuronal cells or stem cells
– Development of high-throughput assays such as ELISA

Interpersonal & communication skills:

  • Excellent presentation skills, backed up by a record of international presentations
  • Excellent interpersonal skills including ability to work effectively within a team
  •  Ability to impart knowledge and skills to graduate students and other members of the research team

Relevant experience:

  • Thorough research experience in molecular biology and neurobiology including developmental neuroscience and cellular biology and signal transduction
  • publication record that demonstrates scientific rigour and productivity, including at least one first-author publication in a high-profile journal

Additional requirements:

  • Ability to manage own workload in an organised way
  • Excellent organisational skills including ability to organize and participate in collaborative research initiatives and projects and to organise and manage laboratory data and reagents
  • Ability to prepare and analyse data for publication in scientific journals and to present scientific data to peers in seminars and at conferences

How to apply:

Apply Online


Please ensure that you upload your Curriculum Vitae (CV) and a covering letter in the Upload section of the online application.

If you have any questions about this vacancy or the application process, please contact Dr. Florian Merkle email: [email protected] or Karen Laurence email: [email protected]

Closing date for receipt of online applications: 16th June, 2016

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