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Grab a package of £42,187 p.a by working as Postdoctoral Training Fellow @ ICR, London

The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.Under the leadership of our Chief Executive, Professor Paul Workman FMedSci, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

Position Title: Postdoctoral Training Fellow (x2) – Vannini Group

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Length of Contract: 2 years

Salary Range: £29,517 – £42,187 p.a. inclusive (full salary scale)

Job Description:

The postdoctoral training fellows will join a dynamic team investigating the structure and function of components of the RNA polymerase III transcription apparatus using a multidisciplinary approach. The aim of this project is elucidate the molecular architecture and function of large macromolecular complexes that assemble at RNA Pol III loci across the eukaryotic genome in order to understand their role in genome organization

Specific duties and responsibilities:
• Large-scale purification of proteins and complexes using bacterial and baculovirus expression systems.

• Biochemical and biophysical analysis of protein-protein and protein-nucleic acid interactions.

• Structural analysis of proteins and complexes.

• Coordination with other members of the team.

• To take an interest in the relevant scientific literature.

• Be familiar with ICR’s approach towards risk management including its policies and procedures, which require all staff to play an active part in identifying and managing risk.

Education & Knowledge:


  • PhD (or equivalent) in biochemistry or molecular biology
  • First degree in a biological science



  • Recombinant protein expression and purification
  • Biochemical characterization of multi-subunit protein complexes
  • Structural biology (X-ray crystallography and/or single particle electron microscopy)
  • Good publication record


  • Biochemistry of multisubunit complexes
  • Protein production in insect cells (MultiBac)



  • Basic molecular biology
  • Protein biochemical and biophysical characterization
  • Competent at laboratory techniques, trouble-shooting etc.
  • Ability to integrate different experimental techniques
  • Good observation skills and ability to keep appropriate records
  • Computer literate with ability to use structural biology software
  • Good organisational skills
  • Good communication skills, verbal and written
  • Highly committed and enthusiastic with willingness to learn new techniques/approaches

How to Apply:

Interested candidates can apply online via the link below.

Apply Online

Closing date for receipt of applications: 15th June, 2016