The antibiotic fluconazole is used against pathogenic fungi. After long-term treatment, resistant organisms can arise. One yeast strain was resistant to 10 g/mL fluconazole, whereas the growth of the wild type was prevented by 5 g/mL. The kinetics of the enzyme that is the target of fluconazole, lanosterol 14-demethylase (14-DM), were determined in the wild type and the resistant yeast, and the curves shown in Figures 1a and 1b were obtained.Which of the following is the effect of fluconazole on the lanosterol 14-DM?

Which of the following is the effect of fluconazole on the lanosterol 14-DM?

a) Competitive inhibition
b) Uncompetitive inhibition
c) Noncompetitive inhibition
d) Irreversible inactivation
 

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