Workplace:     Department of Physiology and Pharmacology
Department / unit or equivalent:     Receptor Biology and Signaling
Form of employment:     Temporary
Scope:     Full-time 

Description of the work group/equivalent and its work/focus:    

The research group (Receptor Biology & Signaling) is focused on the investigation of WNT/Frizzled (FZD) signaling pathways. The aim is to characterize the receptor biology and downstream signaling events of FZD activation in a pharmacological way. The group is embedded in a strong national and international network of collaborators. The PhD project is based on the collaboration between the Schulte laboratory at the Karolinska Institutet and the laboratory of Jeffrey Rubin (National Cancer Institute, Bethesda, MD, USA). For more information: http://ki.se/research/gunnarschulte.

Area of responsibilities/duties:    
We are looking for a highly motivated student for a PhD position within the KI-NIH graduate programme in Neuroscience.
Qualifications:     The applicant should have a profound background in biochemistry, molecular biology, cell biology, cellular signal transduction and neurobiology. Experience in mammalian cell culture, protein biochemistry, molecular biology, tissue processing and staining, and digital data handling (text and images) are required. Further, experiences in (confocal) microscopy and cellular imaging would be advantageous. The project is aiming to characterize WNT/FZD signaling in a detailed molecular pharmacological manner in in vitro cell systems using determination of protein phosphorylation, second messenger production, protein localization and live cell imaging. Further, detection of WNT/FZD signaling components in primary cells (glia and neurons) and brain tissue is planned. Thus, results from this study should increase our knowledge on molecular mechanisms in WNT/FZD signaling and their role in brain homeostasis.

The applicant should be ambitious and devoted to the project and should have a desire to take initiatives and responsibility for running the project. Excellent knowledge in spoken and written English is also required.

Information about graduate studies, eligibility and admission criteria can be found at http://ki.se/ki/jsp/polopoly.jsp?d=270&l=sv.
 

Contact     

Gunnar Schulte
+46 8 524 879 33
gunnar.schulte@ki.se

Union representatives    
1.) Göran Engberg, SACO
+46 8 524 867 17
goran.engberg@ki.se

2.) Monica Marcus, OFR/ST
+46 8 524 879 20
monica.marcus@ki.se

Application procedure:    

Please send your application (via e-mail) in English marked with the reference number 2762/2009, including the following documents to camilla.fors.holmberg@ki.se:

1. A full CV (including publication list if applicable)
2. 2 letters of recommendation
3. A brief outline of your previous and current work, including technical experience from various molecular and cellular biology methods.
4. electronic copy of the masters thesis if applicable
5. A cover letter

Application sent to:    

Karolinska Institutet
Department of Physiology and Pharmacology
Camilla Fors Holmberg
171 77 Stockholm
email:  camilla.fors.holmberg@ki.se
Reference number:     2762/2009
Last date for applications:     August 31 2009

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